Stainless Steel Fermenter

This series of products suits for various kinds of microbiology fermentation test, such as bacteria culture, vaccine, fungi, enzyme, environment, agriculture, pharmacy, and microbiology, etc. This equipment has the following features: excellent stability and convenient operation. Users can...


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Design Instruction

This system a standardized module system designed according to URS and GMP regulation and to the requirement of upstream and downstream processing equipment for biological reaction preparation. It is safe and reliable, easy to operate.

System adopts industrial integrated technology, using Siemens PLC, Siemens HMI and relevant industrial integrated control technology to simplify the complex operation and let the production to be more stable and efficient.

System Configuration

A.  Bioreactor

Bioreactor with 400L working volume (total volume 500L) and diameter-height-ratio at 1:1.3, consisting of inner bladder (316L), jacket (304) and insulation layer (304). It has upper and lower seal heads and barrel flange abutting-joint structure. Design pressure for tank body is 4Bar, for jacket is 6Bar; material contacting part is 316L with inner surface roughness Ra≤0.4um. It meets the requirement of GB150 pressure vessel regulation, and provides qualification certificate by national organization.


Main Functional Configuration of Tank Body

1.  Sight Glass Unit.

2.  Pressure Differential Level Meter (LABOM, German).

3.  Pressure Sensor (LABOM, German).

4.  Pressure Gauge (BLD).

5.  Rupture Disc (Huali).

6.  Respirator (Millipore 0.22um PTFE).

7.  CIP/SIP Nozzle (Spray Ball from Germany Neumo).

8.  Water Inlet Nozzle.

9.  Temperature Sensor (JUMO).

10.PH Meter (M.T).

11.DO Electrode.

12.Feeding Nozzle.

13.Sterile Sampling Valve (Rotech).

14.Bottom Valve (German, Gemu).

15.High-performance Mechanical Stirrer with Double Mechanical Sealing (Rotech) .

16.Inlet/Outlet of Jacket.

B.  Pipeline System Part

Pipeline System part; Fluid inlet pipe, valve, material supplementary device, material transmit pipeline and auxiliary pipeline for CIP/SIP.


Functional Components for Pipeline System

1.  Air Regulating Valve (Fersto).

2.  Steam Trap (Spiraxsarco).

3.  BPE Sanitary Pipeline (CSE).

4.  Steam Pressure Regulating Valve (Spiraxsarco).

5.  GMP Valve (Gemu PTFE+EPDM).

6.  Pneumatic Diaphragm Valve (Gemu PTFE+EPDM).

7.  Mass Flowmeter.

8.  Proportioning Valve.

9.  Exhaust Filter.

10.Inlet Filter.

11.Peristaltic Pump……

C.Electrical Control System

Electrical control system consists of Siemens PLC, I/O module, HMI, pneumatic control island, instrument and appliance, actuator, performance feedback, alarm, power line, signal transmission circuit and stainless steel electrical control cabinet and so on;

DEquipment Frame

It consists of 304 stainless steel rectangular pipe, square pipe and auxiliary components in integrated welding, used for the supporting and orientation of whole system and guarantee of the integrity of equipment.

NoParameter nameTechnical indicator
1Total volumeFrom 5L to 30000L

1.On-line check and measure, and digitization fully automatic control

.2.PH, acid and base gang control.  Peristaltic pump automatically adjust to feed acid and base.

3.Control range 2-12pH, measure precision ± 0.01 pH, control precision ± 0.01 pH.

4. It has auto alarm function.

5.pH sensor and signal transmission line.

3DO control

1.On-line check and measure, DO and rotate speed gang control

.2.Range 0-100% or 0-200%, precision ± 1%.

3. It has auto alarm function.

4. DO sensor and signal transmission line.

4Foam control

1.Automatically control and automatically alarm

.2.Eletrode check, peristaltic pump automatically add defoamer.

5Feed control

1.Maunally control

. 2.Automatically add according to fixed max. height

6Temp. control

1.PID fully digitization signal   processing, digitization control settings.

2.Circulating water automatically control temperature.

3.Measure range 0-150 degree, control range 15-45 degree, control precision ± 0.5degree.

4.Pt 100 Ω temp. Sensor

7Rotate speed

1.Fully automatic control settings, With   automatic alarm function.

2.Speed range, please check the drawing, precision ± 1%.

3.It is mechanical agitator, turbine   type, vertical impeller.



Manually contro Automatic control(optional)

9PressureChecking by pressure gauge, manually control, range 0-0.4Mpa. automatic control (optional)
10Air flowDisplay on the rotormeter. automatic adjust(optional)
Remarks: the table is only for reference,   if client have difference requirement on the control points, we can also make   according to client requirement.

1.  Technical service: provide free consultation and suggestion, technical support and service by email/fax/telephone and lifetime technical support.

2.  Customized service: product development and design according to different customer's different requirements.

3.  After-sale service team: technical engineers available to service overseas if needed.

4.  Installation: we can arrange engineers to install machines in customer's factory.

5.  Maintenance: reply will be given within 48 hours once customer inform us any malfunction happened, we can also arrange engineers to customer's factory to main machines.

6.  Training: normal machine is properly adjusted before delivery, you will be able to use the machines immediately and you will be able to get free training advice towards our machine in our factory.

7.  Warranty: one year since the date of delivery.

There are multiple models of one type machine , we need to know more details about your products in order that we can recommend the most suitable machine for you. Our questions as below:

1.  What's your product ? please send one picture to us

2.  What's the dimension or specification of your product ?

3.  What's the filling volume of your product ?

4.  What's the production capacity of your required machines?

5.  If possible , please tell us your production process, we can select the approximate machine according to your requirements.

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