The Rotech Single-Use Fermentor (S.U.F) was designed to meet your unique and rigorous needs for microbial applications, while maintaining the flexibility, ease of use, and efficiency found with our single- use systems.
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Designed for the unique requirements of microbial fermentation
Designed to meet your needs
The Rotech Single-Use Fermentor (S.U.F) was designed to meet your unique and rigorous needs for microbial applications, while maintaining the flexibility, ease of use, and efficiency found with our single- use systems.
Robust and scalable
The Rotech S.U.F. and Rotech BioProcess Container (BPC) system use traditional stainless steel fermentor engineering principles to meet the high demands of industrial microbiology with efficient mass transfer, mixing, and temperature control.
The complete line of Rotech S.U.F. systems offer
(1)30 L and 300 L working volume with a 5:1 turndown ratio.
(2)Vertically centered, top-driven impeller locations for powerful mixing.
(3)Consistent scalability from process development through production.
Powerful and efficient
The Rotech S.U.F. and BPC system is designed to deliver optimal growth of microorganisms through high gas flow rates, powerful agitation, and efficient cooling. Purpose-built to match the process demands of traditional clean-in-place and steam in-place (CIP/SIP) stainless steel fermentors, the S.U.F. design makes the transition from traditional to single-use fermentors straightforward and easy.
The system offers
(1)Powerful mixing from a top-driven shaft with three Rushton impellers in a baffled vessel.
(2)Controlled, flexible delivery of air and oxygen through drilled-hole spargers.
(3)Reliable off-gassing with proprietary exhaust management system.
(4)Increased cooling capacity with 3:1 aspect ratio that maximizes surface area.
(5)Automated foam control to reduce the risk of excess foam buildup.
(6)Robust BPC design with integrated sensor technology.
The S.U.F. BioProcess Container: Quality and flexibility
Rotech BPCs are available for the S.U.F. in standard or customized configurations, with your choice of Rotech Film. The BPC includes a three-Rushton impeller assembly, sparger, vent filter, and integrally sealed ports for sensor probes and line set additions. The innovative exhaust management system effectively condenses exhaust gases and transfers condensate back into the fermentor, preventing potential vent filter blockage and bag pressurization.
Custom BPCs accommodate a range of applications. A variety of components have been qualified to maximize design flexibility, including
(1)Single-use sensors.
(2)Tubing and clamps.
(3)Connector types.
Tank design: Ergonomic and elegant
The S.U.F. tank has an ergonomic design, compact footprint, and is highly configurable through an open-architecture approach. The single-use format eliminates time-consuming CIP/SIP procedures.
Features include
(1)Simplified BPC loading with a vertical access door.
(2)Clear access to harvest lines with the open-frame design.
(3)Water jacket for effective heat transfer.
(4)Easy setup of the BPC with the drive shaft.
Controllers and options: Adaptability and choice
The Rotech S.U.F. offers a choice of control systems in either an open-architecture or turnkey system. An open-architecture system allows you to integrate with any controller, perhaps one already in use in your facility. Alternatively, the S.U.F. can be supplied as a ready-to-use, turnkey system with Rotech controller.
Additional options include
(1)Load cells.
(2)Exhaust gas vent filter heater.
(3)Cable management tree.
(4)Electrical box for remote agitation control.
Note: Water jacket systems require an external temperature control unit.
Technical support
Knowledgeable and comprehensive.
Our global field-based technical support team is here to help you every step of the way with local installation and technical support.
We can also provide you with additional support documentation upon request.
All systems are supplied with
(1)Comprehensive user's guide.
(2)Equipment turnover package.
(3)Validation guide.
System specifications
BGL/YCX bioreactor | 50L | 100L | 250L | 500L | 1000L | 2000L |
Rated liquid work volume | 50L | 100L | 250L | 500L | 1000L | 2000L |
Lowest liquid working volume | 25L | 50L | 125L | 250L | 500L | 1000L |
Total volume (Liquid and gas) | 65.5L | 120L | 316L | 660L | 1320L | 2575L |
Fermentation vessel(BPC) Chamber diameter | 34.9 cm | 43.8 cm | 59.7 cm | 75.56 cm | 95.9 cm | 119.4 cm |
Fermentation vessel BPC Chamber shoulder height | 80 cm | 95.3 cm | 115. cm | 144.78 cm | 200.7 cm | 229.9 cm |
Liquid height@Rated working volume | 52.1cm | 66 cm | 91.4 cm | 113.36 cm | 142.2 cm | 178.7 cm |
Impeller (Number x number of leaves) | 1*3 | 1*3 | 1*3 | 1*3 | 1*3 | 1*3 |
Diameter of impeller (CM) | 11.75 | 14.6 | 20 | 25.09 | 32.1 | 39.8 |
Power supply requirements(Voltage, phase, ampere) | 220VAC single 10A | 220VAC single 10A | 220VAC single 10A | 220VAC single 20A | 220VAC single 30A | 220VAC single 60A |
Tank manufacturing materials | SUS304 | SUS304 | SUS304 | SUS304 | SUS304 | SUS304 |
Total width of tank (cm) | 66 | 75 | 66 | 100 | 102 | 132 |
Total length of tank (cm) | 92 | 106.68 | 88.9 | 133 | 132 | 137 |
Overall height of tank (cm) | 134 | 143 | 152 | 231 | 229 | 321 |
Stirring speed (Revolutions per minute) | 30-200 | 30-200 | 30-150 | 30-150 | 20-110 | 20-75 |
Operating temperature (Heater) | Environment temperature to 40℃ | Environment temperature to 40℃ | Environment temperature to 40℃ | Environment temperature to 40℃ | Environment temperature to 40℃ | Environment temperature to 40℃ |
Motor rated power | 0.25 horsepower | 0.25 horsepower | 0.25 horsepower | 0.5 horsepower | 0.5 horsepower | 0.5 horsepower |
Weighing sensor(pc) | 3 | 3 | 3 | 3 | 3 | 3 |
System overview
S.U.F. hardware unit | |
Available in turnkey format | Complete mixing system with a water jacket for temperature control |
Drive shaft inserts into the BPC through the mixing drive motor and locks into the BPC agitator assembly | |
S.U.F. BPC | |
Supplied sterile and ready to use | Agitator assembly is a single-use (polyethylene) impeller with a bearing/seal assembly linked to an external mixer drive |
Gas control with drilled-hole spargers | |
Exhaust management system with options for multiple vent filters based on gas flow needs | |
Integrally sealed ports in the S.U.F. BPC allows for sensor probes and line sets addition | |
Available in Rotech CX5-14 and Aegis5-14 film options | |
System options | |
Adaptable to your needs | Exhaust condenser unit |
Exhaust gas vent filter heater | |
Integrated foam sensor | |
Load cells (3) | |
Cable management tree | |
Process control system | |
Optional electrical box for remote agitation control- S.U.F.s require a separate external temperature control unit | |
Choose an open-architecture approach or a turnkey, ready-to-use S.U.F. system |
See the other products and services-we offer for your bioproduction needs
(1)Single-use technologies
Our single-use technologies are standard and customizable systems, from upstream to downstream bioprocessing. Rotech single-use bioreactors, fermentors, mixers, and bioprocess containers are relied upon across the workflow for rapid changeover and ease of use.
(2)Cell culture products
Our RotechBio offers a full array of innovative performance products and knowledge-based services, including fast and flexible cell line development, media and feeds, class-setting technologies, quality custom media development, and media optimizing services.
(3)Protein purification and chromatography
We offer a full range of purification technologies, from affinity to ion exchange to reversed-phase chromatography. When capacity, resolution, and yield are critical, choose Rotech BIOS resins for excellent downstream mAb and recombinant protein chromatography results. Rotech bio affinity ligands provide purification that’s stable, specific, and designed for virtually any target.
(4)Analytical solutions
Trust our SEQ analytical solutions for contaminant identification and detection. Our analytical solutions use rapid molecular methods for pharmaceutical manufacturing to help ensure the quality and safety of your pharmaceutical products, especially when accuracy and time-to results are critical. Our comprehensive group of bioprocessing portfolios provides you with innovative solutions and exceptional customer service for every stage of bioproduction. Our products and services are backed by decades of expertise and dedication, providing you with the quality and innovation you need and deserve. Let's move forward together.
Integrated solutions for bioproduction
(1)Single-Use Mixers (S.U.M.s)
A variety of options up to 5,000 L for both upstream and downstream applications.
(2)Liquid- and dry-format media
We offer both custom manufacturing and a full range of chemically defined performance media and supplement products.
(3)BioProcess Containers (BPCs)
A variety of configurations up to 2,000 L for liquid harvest, storage, and transportation.
(4)Sera
Our sera are the industry standards for consistent quality and reliability.
(5)Single-Use Bioreactors (S.U.B.s)
50–2,000 L bioreactors capable of integrating with an existing control system. Buffers and process li Custom and standard buffers and process liquids, including Gibco Water for Injection (WFI) quality water.
(6)Buffers and process liquids
Custom and standard buffers and process liquids, including Gibco Water for Injection (WFI) quality water.
(7)Heat transfer
A modular heat exchanger which utilizes BPCs as the sterile fluid path.
1. Technical service: provide free consultation and suggestion, technical support and service by email/fax/telephone and lifetime technical support.
2. Customized service: product development and design according to different customer's different requirements.
3. After-sale service team: technical engineers available to service overseas if needed.
4. Installation: we can arrange engineers to install machines in customer's factory.
5. Maintenance: reply will be given within 48 hours once customer inform us any malfunction happened, we can also arrange engineers to customer's factory to main machines.
6. Training: normal machine is properly adjusted before delivery, you will be able to use the machines immediately and you will be able to get free training advice towards our machine in our factory.
7. Warranty: one year since the date of delivery.
There are multiple models of one type machine , we need to know more details about your products in order that we can recommend the most suitable machine for you. Our questions as below:
1. What's your product ? please send one picture to us
2. What's the dimension or specification of your product ?
3. What's the filling volume of your product ?
4. What's the production capacity of your required machines?
5. If possible , please tell us your production process, we can select the approximate machine according to your requirements.