Single-Use Fermenter

The Rotech Single-Use Fermentor (S.U.F) was designed to meet your unique and rigorous needs for microbial applications, while maintaining the flexibility, ease of use, and efficiency found with our single- use systems.


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Designed for the unique requirements of microbial fermentation

Designed to meet your needs

The Rotech Single-Use Fermentor (S.U.F) was designed to meet your unique and rigorous needs for microbial applications, while maintaining the flexibility, ease of use, and efficiency found with our single- use systems.

Robust and scalable

The Rotech S.U.F. and Rotech BioProcess Container (BPC) system use traditional stainless steel fermentor engineering principles to meet the high demands of industrial microbiology with efficient mass transfer, mixing, and temperature control.

The complete line of Rotech S.U.F. systems offer

(1)30 L and 300 L working volume with a 5:1 turndown ratio.

(2)Vertically centered, top-driven impeller locations for powerful mixing.

(3)Consistent scalability from process development through production.


Powerful and efficient

The Rotech S.U.F. and BPC system is designed to deliver optimal growth of microorganisms through high gas flow rates, powerful agitation, and efficient cooling. Purpose-built to match the process demands of traditional clean-in-place and steam in-place (CIP/SIP) stainless steel fermentors, the S.U.F. design makes the transition from traditional to single-use fermentors straightforward and easy.

The system offers

(1)Powerful mixing from a top-driven shaft with three Rushton impellers in a baffled vessel.

(2)Controlled, flexible delivery of air and oxygen through drilled-hole spargers.

(3)Reliable off-gassing with proprietary exhaust management system.

(4)Increased cooling capacity with 3:1 aspect ratio that maximizes surface area.

(5)Automated foam control to reduce the risk of excess foam buildup.

(6)Robust BPC design with integrated sensor technology.

The S.U.F. BioProcess Container: Quality and flexibility

Rotech BPCs are available for the S.U.F. in standard or customized configurations, with your choice of Rotech Film. The BPC includes a three-Rushton impeller assembly, sparger, vent filter, and integrally sealed ports for sensor probes and line set additions. The innovative exhaust management system effectively condenses exhaust gases and transfers condensate back into the fermentor, preventing potential vent filter blockage and bag pressurization.

Custom BPCs accommodate a range of applications. A variety of components have been qualified to maximize design flexibility, including

(1)Single-use sensors.

(2)Tubing and clamps.

(3)Connector types.

Tank design: Ergonomic and elegant

The S.U.F. tank has an ergonomic design, compact footprint, and is highly configurable through an open-architecture approach. The single-use format eliminates time-consuming CIP/SIP procedures.

Features include

(1)Simplified BPC loading with a vertical access door.

(2)Clear access to harvest lines with the open-frame design.

(3)Water jacket for effective heat transfer.

(4)Easy setup of the BPC with the drive shaft.

Controllers and options: Adaptability and choice

The Rotech S.U.F. offers a choice of control systems in either an open-architecture or turnkey system. An open-architecture system allows you to integrate with any controller, perhaps one already in use in your facility. Alternatively, the S.U.F. can be supplied as a ready-to-use, turnkey system with Rotech controller.


Additional options include

(1)Load cells.

(2)Exhaust gas vent filter heater.

(3)Cable management tree.

(4)Electrical box for remote agitation control.

Note: Water jacket systems require an external temperature control unit.

Technical support

Knowledgeable and comprehensive.

Our global field-based technical support team is here to help you every step of the way with local installation and technical support.

We can also provide you with additional support documentation upon request.

All systems are supplied with

(1)Comprehensive user's guide.

(2)Equipment turnover package.

(3)Validation guide.

System specifications

BGL/YCX bioreactor50L100L250L500L1000L2000L
Rated liquid work volume50L100L250L500L1000L2000L
Lowest liquid working volume25L50L125L250L500L1000L
Total volume (Liquid   and gas)65.5L120L316L660L1320L2575L
Fermentation vessel(BPC) Chamber diameter34.9   cm43.8   cm59.7   cm75.56   cm95.9   cm119.4   cm

Fermentation vessel 

BPC Chamber shoulder height

80   cm95.3   cm115.   cm144.78   cm200.7   cm229.9   cm
Liquid height@Rated working volume52.1cm66   cm91.4   cm113.36   cm142.2   cm178.7   cm
Impeller (Number x number of leaves)1*31*31*31*31*31*3
Diameter of impeller (CM)11.7514.62025.0932.139.8
Power supply requirements(Voltage,   phase, ampere)



















Tank manufacturing materialsSUS304SUS304SUS304SUS304SUS304SUS304
Total width of tank (cm)667566100102132
Total length of tank (cm)92106.6888.9133132137
Overall height of tank (cm)134143152231229321
Stirring speed (Revolutions per minute)30-20030-20030-15030-15020-11020-75
Operating temperature (Heater)Environment   temperature to 40℃Environment   temperature to 40℃Environment   temperature to 40℃Environment   temperature to 40℃Environment   temperature to 40℃Environment   temperature to 40℃
Motor rated power0.25   horsepower0.25   horsepower0.25   horsepower0.5   horsepower0.5   horsepower0.5   horsepower
Weighing sensor(pc)333333


System overview

S.U.F. hardware unit
Available in turnkey formatComplete mixing system with a water jacket   for temperature control
Drive shaft inserts into the BPC through the   mixing drive motor and locks into the BPC agitator assembly
Supplied sterile and ready to useAgitator assembly is a single-use   (polyethylene) impeller with a bearing/seal assembly linked to an external mixer drive
Gas control with drilled-hole spargers
Exhaust management system with options for   multiple vent filters based on gas flow needs
Integrally sealed ports in the S.U.F. BPC   allows for sensor probes and line sets addition
Available in Rotech CX5-14 and Aegis5-14   film options
System options
Adaptable to your needsExhaust condenser unit
Exhaust gas vent filter heater
Integrated foam sensor
Load cells (3)
Cable management tree
Process control system
Optional electrical box for remote agitation   control- S.U.F.s require a separate external   temperature control unit
Choose an open-architecture approach or a   turnkey, ready-to-use S.U.F. system

See the other products and services-we offer for your bioproduction needs    

(1)Single-use technologies    

Our single-use technologies are standard and customizable systems, from upstream to downstream bioprocessing. Rotech single-use bioreactors, fermentors, mixers, and bioprocess containers are relied upon across the workflow for rapid changeover and ease of use.    

(2)Cell culture products    

Our RotechBio offers a full array of innovative performance products and knowledge-based services, including fast and flexible cell line development, media and feeds, class-setting technologies, quality custom media development, and media optimizing services.    

(3)Protein purification and chromatography    

We offer a full range of purification technologies, from affinity to ion exchange to reversed-phase chromatography. When capacity, resolution, and yield are critical, choose Rotech BIOS resins for excellent downstream mAb and recombinant protein chromatography results. Rotech bio affinity ligands provide purification that’s stable, specific, and designed for virtually any target.    

(4)Analytical solutions    

Trust our SEQ analytical solutions for contaminant identification and detection. Our analytical solutions use rapid molecular methods for pharmaceutical manufacturing to help ensure the quality and safety of your pharmaceutical products, especially when accuracy and time-to results are critical.    Our comprehensive group of bioprocessing portfolios provides you with innovative solutions and exceptional customer service for every stage of bioproduction. Our products and services are backed by decades of expertise and dedication, providing you with the quality and innovation you need and deserve. Let's move forward together.    


Integrated solutions for bioproduction    

(1)Single-Use Mixers (S.U.M.s)    

A variety of options up to 5,000 L for both upstream and downstream applications.    

(2)Liquid- and dry-format media    

We offer both custom manufacturing and a full range of chemically defined performance media and supplement products.    

(3)BioProcess Containers (BPCs)    

A variety of configurations up to 2,000 L for liquid harvest, storage, and transportation.    


Our sera are the industry standards for consistent quality and reliability.    

(5)Single-Use Bioreactors (S.U.B.s)    

50–2,000 L bioreactors capable of integrating with an existing control system.  Buffers and process li    Custom and standard buffers and process liquids, including Gibco Water for Injection (WFI) quality water.

(6)Buffers and process liquids    

Custom and standard buffers and process liquids, including Gibco Water for Injection (WFI) quality water.

(7)Heat transfer

A modular heat exchanger which utilizes BPCs as the sterile fluid path.

1.  Technical service: provide free consultation and suggestion, technical support and service by email/fax/telephone and lifetime technical support.

2.  Customized service: product development and design according to different customer's different requirements.

3.  After-sale service team: technical engineers available to service overseas if needed.

4.  Installation: we can arrange engineers to install machines in customer's factory.

5.  Maintenance: reply will be given within 48 hours once customer inform us any malfunction happened, we can also arrange engineers to customer's factory to main machines.

6.  Training: normal machine is properly adjusted before delivery, you will be able to use the machines immediately and you will be able to get free training advice towards our machine in our factory.

7.  Warranty: one year since the date of delivery.

There are multiple models of one type machine , we need to know more details about your products in order that we can recommend the most suitable machine for you. Our questions as below:

1.  What's your product ? please send one picture to us

2.  What's the dimension or specification of your product ?

3.  What's the filling volume of your product ?

4.  What's the production capacity of your required machines?

5.  If possible , please tell us your production process, we can select the approximate machine according to your requirements.

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